Data of type physico-chemistry measured on Nesque basin within the framework of the FONTAINE DE VAUCLUSE observatory, that is part of the KARST observatory network. The KARST observatory network aims to strengthen knowledge-sharing and to promote cross-disciplinary research on karst systems, in the framework of the OZCAR Critical Zone network Research Infrastructure.Data consist in 6 time series on 2 station(s). The measured parameters are: Conductivity (µS/cm), Total organic carbon (TOC) (mg/L), Water temperature (°C).Measurements start on 12-03-2020 and end on 18-10-2021