Data of type physico-chemistry measured on Fontaine de Vaucluse basin within the framework of the FONTAINE DE VAUCLUSE observatory, that is part of the KARST observatory network. The KARST observatory network aims to strengthen knowledge-sharing and to promote cross-disciplinary research on karst systems, in the framework of the OZCAR Critical Zone network Research Infrastructure.Data consist in 23 time series on 8 station(s). The measured parameters are: Conductivity (µS/cm), Total organic carbon (TOC) (mg/L), Water temperature (°C).Measurements start on 12-02-1991 and end on 18-10-2021