The purpose of this study was to investigate sex differences in fatigability and recovery from resistance exercise. Male and female subjects with at least one year of bench press experience (N = 21 males and 21 females) performed a fatigue protocol consisting of barbell bench press with 75% 1RM loads for sets of 5 repetitions, with 90 seconds between sets, until concentric failure. Recovery was monitored for the subsequent 72 hours using subjective ratings of soreness and estimated 1RM strength derived from load-velocity profiles. The female subjects completed more reps during the fatigue protocol (Females: 58.3 ± 27.3; Males: 29.6 ± 10.6; p = 0.0001), but post-training soreness and recovery of estimated 1RM strength did not significantly differ between sexes. Results suggest that women fatigue slower than men during multiple sets of bench press, and can recover from training at a similar rate despite completing a larger relative workload.