The purpose of this study was to assess the oral health knowledge, oral health-related quality of life (QOL) and access to dental care issues of the Lumbee tribe in Robeson County, North Carolina (NC). Lumbee Indians attending the Lumbee Homecoming Festival volunteered to complete a self-administered survey. This study revealed that there was low knowledge regarding the link between oral and systemic health. Many believed that it is natural to loose your teeth as you get older. Oral health-related QOL was affected by oral pain, altered taste, and feeling self-conscious because of oral problems. Barriers to accessing dental care included being unable to find a dentist, not being able to miss work to go to the dentist, dental fear, and cost of dental services.