Pressure injuries affect more than 2.5 million individuals each year and cost between 9 and 11 billion dollars to treat. The importance of adequate energy and protein supplementation to promote the healing of wounds, such as pressure injuries, has been well established, however the role of micronutrients, specifically the amino acids arginine and glutamine, the metabolite HMB, vitamins A and C, and the mineral zinc, is less clear. 10 studies, 2 literature reviews and 2 systematic reviews/meta-analysis were included in this review with outcomes focused on indicators of pressure injury healing. While many studies contain significant limitations related to sample size and length of study, the overall results of supplementation show promise in the treatment of pressure injuries, especially in the setting of existing malnutrition and likely deficiency. Pressure injuries are associated with many negative health outcomes that can prolong immobility, compromise nutrition and contribute to morbidity and mortality. The drawbacks to supplementation are minimal and far outweighed by the positive effects.