Background: Among people living with human immunodeficiency virus (HIV), oral care is among the highest unmet needs affecting quality of life and overall wellness. The impact of prosthodontic treatment on HIV patients has not been comprehensively documented. Objective: The purpose of this study is to investigate the relationship between prosthodontic rehabilitation and different quality of life measures in HIV-positive subjects before and after prosthodontic treatment. Methods: A convenience sample of HIV positive subjects (n=22) were rehabilitated with removable prostheses: complete dentures, immediate dentures, cast or acrylic partial dentures; mean age 46; 78% men. Four validated questionnaires were administered at 6-month intervals over a 24-month period: OHIP-14 (Oral Health Impact Profile), SF-8 (Medical Outcomes Short Form 8), SADS (Social Avoidance and Anxiety) and FAY (Feelings About Yourself). Wilcoxon signed-rank tests compared average questionnaire responses before treatment to average questionnaire responses after treatment. Results: Clinical measures included CD4 count, HIV viral load, oral signs and symptoms, and stage of HIV. P-values