Spark plasma sintering (SPS) is a novel technique to fabricate advanced materiales. This Thesis describes the origin, mechanism and development of the SPS as well as its applications in nanomaterials synthesis, diamond synthesis and biomaterials synthesis especially titanium based biomaterials. Chapter 1 introduces the background. Chapter 2 concerns the study on the indirect evidences for the presence of plasmas in SPS. Chapter 3 reports the synthesis of diamond from nanocarbon and graphite by SPS. Chapter 4 and 5 studies the SPS of titanium alloys and foams for biomedical applications.