Nowadays, hazardous organic compounds like pharmaceuticals and personal care products (PPCPs) are frequently found as contaminants in water, especially in low (ppb-ppt scale) concentrations. In this work five types of titania and zinc oxide based photocatalysts with different particle size, texture and morphology have been synthesized. These materials show high photocatalytic activity and excellent performance in the remediation of water from pharmaceutical contaminations at low drug concentration. These results are new and these conditions (photocatalytic and low concentration) have been not considered so far.