Toxicity of nanoparticles have raised concerns about their potential effects on coastal ecosystems, yet the mechanisms of the nanoparticle toxicity and their interactions with common abiotic stressors such as temperature and salinity are not well understood. The aim of our present study was to investigate the combined effects of seasonal warming, acclimation at elevated temperatures and salinity stress on bioenergetics, immune and general cellular stress responses to nZnO nanoparticles pollution in the blue mussels M. edulis.