Oxyurid nematodes from the hindgut of the Ethiopian endemic rodent, Stenocephalemys albipes Rüppell, 1842, were examined and found to represent a new species of the genus Syphacia Seurat, 1916, Syphacia ethiopiana sp. n. The new species is morphologically similar to the common intestinal nematode of mice, Syphacia obvelata (Rudolphi, 1802) Seurat, 1916, but differs significantly in the nucleotide sequences of ITS rDNA and LSU rDNA. SEM images of the cuticular surface of the anterior end and other structures are provided.