Developments in science, technologies, complexity of industrial infrastructure facilities sustaining life necessary systems are associated with an increased dangers of their functioning at all stages of the life cycle. These dangers are characterized by man-made risks that determine the likelihood of hazardous processes and damage from them. Industry-related risks together with natural and anthropogenic risks are integral risks. The tasks of ensuring safety are coming down to the achievement through calculations and experiments of an acceptable level of risks with the necessary estimated economic costs. Approbation of the described approach is carried out on the example of nuclear power plants.