Complexity, defined as the coexistence of functional differentiation and functional integration is a general property of thalamo-cortical circuits that can be characterized at multiscale level. Previously, we mainly focused on the relationship between slow waves and complexity, explored by perturbations and electrophysiological recordings, from micro- to macro-scale. The final goal was to link dynamics occurring at the micro-scale, such as sleep-like neuronal bistability, to the collapse/emergence of global patterns of complex interactions among brain areas at the macroscale. At the mesoscale level, we combined for the first time in this dataset (Pigorini et al. in prep.) intracortical single pulse electrical stimulation (SPES) in humans undergoing pre-surgical evaluation, with simultaneous intracortical recordings (stereo-EEG) and high-density electroencephalography (hd-EEG, 256 channels) during both wakefulness and sleep. Local perturbations with SPES allow studying bistable dynamics (downstates in the Local Field Potential) and their effects on local cortico-cortical interactions (Pigorini et al. 2015). Adding simultaneous hd-EEG links these intracortical events to overall connectivity and complexity as assessed at the scalp level (Casali et al. 2013, Sci Tr Med). The data is organized in two conditions (sessions): wakefulness and sleep. Subjects were patients that were undergoing intracranial monitoring for surgical planning due to refractory epilepsy. The project was approved by the responsible ethics committee (Comitato Etico Milano Area C - Ospedale Niguarda, Milano, Italy), all subjects provided informed consent and the experiments were carried out in accordance to the Declaration of Helsinki. **References:** **Pigorini et al. (2015)** Bistability breaks-off deterministic responses to intracortical stimulation during non-REM sleep. *NeuroImage*, vol: 112, pp:105--113; doi: [10.1016/j.neuroimage.2015.02.056](https://doi.org/10.1016/j.neuroimage.2015.02.056) **Casali et al. (2013)** A theoretically based index of consciousness independent of sensory processing and behavior. *Science Translational Medicine*, vol: 5, issue: 198, pp. 198ra105; doi: [10.1126/scitranslmed.3006294](https://doi.org/10.1126/scitranslmed.3006294 ) **Funding:** This project/research has received funding from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2).