Second nearest-neighbor modified embedded-atom method (MEAM) interatomic potentials for the Ni–H binary system has been developed on the basis of previously developed MEAM potentials of pure Ni and H. The potential can describe various fundamental physical properties of the relevant binary alloys (structural, thermodynamic, defect, and dynamic properties of metastable hydrides or hydrogen in face-centered cubic solid solutions) in good agreement with experiments or first-principles calculations.