A semi-empirical Modified Embedded Atom Method (MEAM) potential is developed for application to the high-temperature body-centered-cubic uranium-zirconium alloy (gamma-UZr) phase and employed with molecular dynamics (MD) simulations to investigate the high-temperature thermophysical properties of UeZr alloys. The potential was constructed to ensure that basic properties (e.g., elastic constants, bulk modulus, and formation energies) were in agreement with first-principles calculations and experimental results. After which, slight adjustments were made to the potential to fit the known thermal properties and thermodynamics of the system. The potentials successfully reproduce the experimental melting point, enthalpy of fusion, volume change upon melting, thermal expansion, and the heat capacity of pure U and Zr. Simulations of the U-Zr system are found to be in good agreement with experimental thermal expansion values, Vegard's law for the lattice constants, and the experimental enthalpy of mixing.