This data set contains estimated hourly CO2 atmospheric mole fractions and meteorological observations over North America for the year 2010 at a horizontal grid resolution of 27 km and vertical resolution from the surface to 50 hPa. The data are output from the Penn State WRF-Chem version of the Weather Research and Forecasting (WRF) model using lateral boundary conditions and surface fluxes from the CMS-Flux Inversion system.