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This data set provides gridded, model-derived gross primary productivity (GPP), ecosystem respiration (RECO), and net ecosystem exchange (NEE) of CO2 biogenic fluxes and their uncertainties at monthly and 3-hourly time scales over 2003-2019 on a 463-m spatial resolution grid for the conterminous United States (CONUS) and on both 5-km and half-degree spatial resolution grids for North America (NA). The biogeochemical model Carnegie Ames Stanford Approach (CASA) was used.