This dataset provides hourly urban greenhouse gas measurements for cities in the CO2 Urban Synthesis and Analysis (CO2-USA) Data Synthesis Network for 2000 to 2019. Measurements include carbon dioxide (CO2), methane (CH4), and carbon monoxide (CO) concentrations measured at hourly intervals at multiple sites within the U.S. cities of Boston, Indianapolis, Los Angeles, Portland, Salt Lake City, San Francisco, and Washington DC/Baltimore, and Toronto, Canada.