This dataset includes above water measurements of remote-sensing reflectance measured in situ at field sampling stations during the Delta-X 2021 field efforts. Measurements were collected in the Atchafalaya River and Terrebonne Basins on the southern coast of Louisiana from 2021-03-25 to 2021-04-22 (spring) and from 2021-08-14 to 2021-09-24 (fall). Field sampling was paused on 2021-08-25 and resumed on 2021-09-13 due to the landfall of Hurricane Ida on 2021-08-26 approximately 70 km east of the study site. Water quality changes caused by the hurricane were expected to be minimal. Reflectance was measured near-simultaneously with collection of field samples and in-water sediment parameters in multiple channels of varying width (from a few meters to >100 m), near Delta-X intensive study sites, in open bays and lakes, and at a few locations in the nearshore Gulf of Mexico. For each in situ collection, a handheld Portable SpectroRadiometer (PSR-1100f, Spectral Evolution) was used to measure radiance from: (a) a highly reflective (>99% reflectance) Lambertian Spectralon panel (b) from the sky, measured at 40 degrees from the solar zenith and at 135 degrees from the sun azimuthal plane, (c) from the water, measured at 40 degrees from nadir and at 135 degrees from the sun azimuthal plane. These measurements were used to calculate remote-sensing reflectance and the water-leaving radiance relative to downwelling irradiance, including a correction for the influence of reflected skylight. These data are provided in comma-separated values (CSV) format.