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The human adult intestinal system is a complex organ that is approximately
9 meters long and performs a variety of complex functions including
digestion, nutrient absorption, and immune surveillance. We performed
snATAC-seq on 8 regions of of the human intestine (duodenum,
proximal-jejunum, mid-jejunum, ileum, ascending colon, transverse colon,
descending colon, and sigmoid colon) from 9 donors (B001, B004, B005,
B006, B008, B009, B010, B011, and B012). In the corresponding paper, we
find cell compositions differ dramatically across regions of the intestine
and demonstrate the complexity of epithelial subtypes. We map gene
regulatory differences in these cells suggestive of a regulatory
differentiation cascade, and associate intestinal disease heritability
with specific cell types. These results describe the complexity of the
cell composition, regulation, and organization in the human intestine, and
serve as an important reference map for understanding human biology and
disease.
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