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Inspired Therapeutics (Merritt Island, FL) is developing a mechanical
circulatory support (MCS) system designed as a single driver with
interchangeable, extracorporeal, magnetically levitated pumps. The NeoMate
system design features an integrated centrifugal rotary pump, motor, and
controller that will be housed in a single compact unit. Conceptually,
the primary innovation of this technology will be the combination of
disposable, low-cost pumps for use with a single, multi-functional,
universal controller to support multiple pediatric cardiopulmonary
indications. In response to the paucity of clinically available pediatric
devices, Inspired Therapeutics is specifically targeting the underserved
neonate and infant heart failure (HF) patient population first. In this
article, we present the development of the prototype Inspired Therapeutics
NeoMate System for pediatric left ventricular assist device (LVAD)
support, and feasibility testing in static mock flow loops (H-Q curves),
dynamic mock flow loops (hemodynamics), and in an acute healthy ovine
model (hemodynamics and clinical applicability). The resultant
hydrodynamic and hemodynamic data demonstrated the ability of this
prototype pediatric LVAD and universal controller to function over a range
of rotary pump speeds (500-6000 RPM), to provide pump flow rates of up to
2.6 L/min, and to volume unload the left ventricle in acute animals. Key
engineering challenges observed and proposed solutions for the next design
iteration are also presented.
117 views reported since publication in 2022.