# Data usage policy When using this data, you must acknowledge the source by citing the publication "Widespread dose-dependent effects of RNA expression and splicing on complex diseases and traits" (https://doi.org/10.1101/814350).
# GTEx GWAS integration This package contains the application of several GWAS-QTL integration methods. The results were analyzed in [this preprint](https://www.biorxiv.org/content/10.1101/814350v1) about GTEx v8 application to several GWAS traits. ``` . |-- colocalization | |-- coloc | | `-- coloc_enloc_priors_eqtl.tar.gz | |-- enloc | | |-- enloc_eqtl_eur.tar.gz | | `-- enloc_sqtl_eur.tar.gz | `-- eur_ld.bed.gz |-- prediction_models | |-- gtex_v8_expression_mashr_snp_smultixcan_covariance.txt.gz | |-- gtex_v8_splicing_mashr_snp_smultixcan_covariance.txt.gz | |-- mashr_eqtl.tar | `-- mashr_sqtl.tar |-- smr | |-- SMR_gtex_v8_README.txt | `-- SMRresults_GTEx_v8_peQTL5e-08.tar.gz |-- smultixcan | |-- smultixcan_eqtl.tar.gz | `-- smultixcan_sqtl.tar.gz `-- spredixcan |-- spredixcan_eqtl.tar.gz `-- spredixcan_sqtl.tar.gz ``` You can uncompress gzipped tarball packages `*.tar.gz` in a UNIX command line with an instruction such as: ```bash tar -xzvpf smultixcan_eqtl.tar.gz ``` , and the tar packages (`*.tar`) with an analogous instruction: ```bash tar -xvpf mashr_eqtl.tar ``` ## Preliminaries **Finemapping** results are contained in a separate release due to size constraints. GWAS summary statistics for 114 traits were harmonized and imputed to GTEx v8 variants with MAF>0.01 using only european samples. (summary imputation software [here](https://github.com/hakyimlab/summary-gwas-imputation)). Some of the following analyses used the full set of 114 traits, while some focused only on 87 traits whose imputed associations showed no deflation (the imputation algorithm is conservative, and studies with too few available variants have a depleted distribution of association p-values after imputation). The harmonized and imputed GWAS summary statistics are contained in a separate release due to size constraints. For completeness' sake, the imputed summary statistic...