Medical and ontology experts met at a workshop in April 2021 to investigate a new classification for the Mondo ontology that may complement/correspond with the clinical community's approach to disease classification. The “Harrison's Principles of Internal Medicine” textbook (below called ‘Harrison’) has been used as a landmark in medicine, for both trainees and practicing clinicians. The goal of this workshop was to review the high-level classification of Mondo to reflect the organization of Harrison's book of medicine, and thereby offer a clinically oriented view of Mondo (called “Harrison view”). This report summarizes the changes made to the Mondo ontology and the creation of a new “Harrison view” of Mondo.