There are abundant endophytic bacteria, fungi and actinomycetes in medicinal plants. The microorganisms of medicinal plants are inseparable from the growth, reproduction and metabolic activities of their host plants, which can not only affect the formation and content of medicinal components of plants, but also affect the authenticity of Chinese medicinal materials. Angelicae Sinensis Radix, Astragali Radix, Codonopsis Radix, Glycyrrhizae Radix et Rhizoma and Rhei Radix et Rhizoma are traditional Chinese medicinal materials and important sources of clinical medicine. In recent years, more and more research has been done on the microbiome of this medicinal plant. In order to integrate data resources and results of numerous studies and promote comparative studies, literature review and information extraction analysis were carried out, so as to construct a knowledge base of medicinal plant microbiome to assist the research of medicinal plant quality and authenticity. The database covers medicinal plant microorganisms by name, host plant, classification, genus, family, order, class, phylum, function/biological role, technique, sequence length, NCBI reference serial number /GenBank, references and corresponding links. This interface supports the query function of the microbiome content of the above medicinal plants. Therefore, the database will help to provide a research basis for the development and utilization of the microbiome of medicinal plants and provide a reference for the creation of new methods for quality control and authenticity evaluation of medicinal plants.In Version 2, an additional 11 pieces of information have been incorporated for Codonopsis Radix to consider.In Version 3, the number of endophytes in the database was updated to 350.In Version 4, in order to distinguish the origin of host plants, category 'plant source in literature' was added. Meanwhile, the names of host plants were unified as the Latin names, and one duplicate data has been removed.