The main component of this data publication is a dataset of predicted daily nutrient concentrations for NO3-N and TP for 150 monitoring stations along 60 German rivers (main rivers). The aim of this dataset is to fill the data gap of daily nutrient concentrations for a better understanding of nutrient transport from the rivers to the seas. So far, nutrient concentrations are sampled on a fortnightly basis, which can be insufficient for nutrient retention models working on a daily basis. With this method and available datasets, river basin managers have the opportunity to look at nutrient concentrations or load patterns on a finer resolution to adapt their management to improve water quality. The dataset was obtained by a random forest model (RF) based on measured NO3-N and TP concentrations between the years 2000 and 2019. The data was requested or where available downloaded from official websites of the Federal States or River Basins. Different variables for NO3-N and TP were finally considered in the models to produce the RF, like discharge, land use, day of the year.