Supplementary Figure 1 – IAV infection increases inflammation and impairs lung function. Mice were infected intranasally with 104 PFU of IAV or PBS (Mock) and euthanized after 1, 4, 6 and 10 days after infection to access lung function parameters such as the Pressure x Volume curve relation (A), inspiratory capacity (B), dynamic compliance (C) and resistance (D). Total recruitment of leukocytes in the airways was also accessed (E). Results are shown as the mean ± SEM; n = 5-6 mice. *, P < 0.05 and ***, P < 0.001, when compared to Mock or indicated groups. #, P < 0.05 when comparing days 6 and 10 post IAV infection by one-way ANOVA.