Copyright information:Taken from "Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster"Genome Biology 2003;4(8):R50-R50.Published online 15 Jul 2003http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193642.Copyright © 2003 Locke et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Probe RP11-88O16 (red), located in distal human 15q13.3, and probe pDJ-778A2 (green), which hybridizes to the -related PWS/AS breakpoint clusters in 15q11.2 and 15q13.1 clearly demonstrate the inversion of HSA 15q proximal material in chimpanzee . Humans share the ancestral state with gorilla and orangutan . The DAPI image for each chromosome is shown above the hybridization image and centromeres are indicated by the arrows.