The Initial Common Pathway of Inflammation, Disease, and Death, Abstract and Poster presented to American Chemical Society June 10-13, 2012, 86th Colloid & Surface Science Symposium, Johns-Hopkins University, Baltimore, Md, USA
Presentation Abstract
Title: The Initial Common Pathway of Inflammation, Disease, and Death
Presentation Monday, Jun 11, 2012, 5:30 PM - 7:30 PM Time:Category: Biocolloids Abstract:
In reviewing the literature pertaining to interfacial water, colloidal stability, and cell membrane function, we are led to propose that a cascade of events beginning with acute exogenous surfactant-induced interfacial water stress can explain the etiology of sudden death syndrome (SDS), as well as many other diseases associated with modern times. A systemic lowering of serum zeta potential mediated by exogenous cationic surfactant administration is the common underlying pathophysiology. The cascade leads to subsequent inflammation, serum sickness, thrombohemorrhagic phenomena, colloidal instability, and ultimately even death. We propose that a sufficient precondition for sudden death is lowered bioavailability of certain endogenous sterol sulfates, sulfated glycolipids, and sulfated glycosaminoglycans, which are essential in maintaining biological equipose, energy metabolism, membrane function, and thermodynamic stability in living organisms. Our literature review provides the basis for the presentation of a novel theory as to the origin of endogenous bio-sulfates which involves energy transduction from sunlight. Our hypothesis is amply supported by a growing body of data showing that parenteral administration of substances that lower serum zeta potential results in kosmotropic cationic and/or chaotropic anionic interfacial water stress, and the resulting cascade. We define water stress as a property of interfacial water - interfacial tension - which destabilizes enzymes, protein structure, and cell membranes. We believe that, since the initial events in the inflammatory cascade are purely biophysical, an entirely new set of biomarkers should be employed to diagnose, treat, and prevent disease. The generalized Shwartzman reaction, anaphylaxis, and serum sickness are examples of disease processes initiated by exogenous interfacial water stress (EIWS). Activation of the atheromatous plaque in acute coronary syndromes initiates a cascade, often resulting in acute myocardial infarction. We believe that EIWS triggers this activation. Likew...
Presentation Abstract
Title: The Initial Common Pathway of Inflammation, Disease, and Death
Presentation Monday, Jun 11, 2012, 5:30 PM - 7:30 PM Time:Category: Biocolloids Abstract:
In reviewing the literature pertaining to interfacial water, colloidal stability, and cell membrane function, we are led to propose that a cascade of events beginning with acute exogenous surfactant-induced interfacial water stress can explain the etiology of sudden death syndrome (SDS), as well as many other diseases associated with modern times. A systemic lowering of serum zeta potential mediated by exogenous cationic surfactant administration is the common underlying pathophysiology. The cascade leads to subsequent inflammation, serum sickness, thrombohemorrhagic phenomena, colloidal instability, and ultimately even death. We propose that a sufficient precondition for sudden death is lowered bioavailability of certain endogenous sterol sulfates, sulfated glycolipids, and sulfated glycosaminoglycans, which are essential in maintaining biological equipose, energy metabolism, membrane function, and thermodynamic stability in living organisms. Our literature review provides the basis for the presentation of a novel theory as to the origin of endogenous bio-sulfates which involves energy transduction from sunlight. Our hypothesis is amply supported by a growing body of data showing that parenteral administration of substances that lower serum zeta potential results in kosmotropic cationic and/or chaotropic anionic interfacial water stress, and the resulting cascade. We define water stress as a property of interfacial water - interfacial tension - which destabilizes enzymes, protein structure, and cell membranes. We believe that, since the initial events in the inflammatory cascade are purely biophysical, an entirely new set of biomarkers should be employed to diagnose, treat, and prevent disease. The generalized Shwartzman reaction, anaphylaxis, and serum sickness are examples of disease processes initiated by exogenous interfacial water stress (EIWS). Activation of the atheromatous plaque in acute coronary syndromes initiates a cascade, often resulting in acute myocardial infarction. We believe that EIWS triggers this activation. Likew...