Additional file 4. Supplementary Figure 4. Graphical overview of significant associations logGI50 of Indian natural products with gene expression. Shown are significant associations with FDR adjusted p < 0.05, which are listed in Table 2. INPs are presented by colored circles, with colors corresponding to their subtree assignment based on clustering of their logGI50 values (orange for subtree 1, red for subtree 2, and purple for subtree 3). The subtree assignment of the INPs based on the logGI50 values is shown in Fig. 1, Supplementary Fig. 1, Table 1, and Supplementary Table 5. The direction of the arrows corresponds to the negative or positive values of the Spearman correlation coefficient ρ of association between gene expression and logGI50. An arrow toward an INP indicates ρ > 0, when higher gene expression was associated with higher logGI50 values and increased cell line resistance to that INP, whereas an arrow toward a gene indicates ρ < 0, showing that higher gene expression was associated with lower logGI50 values and with increased cell line sensitivity to that INP.