Additional file 6. Supplementary Figure 6. Graphical overview of significant associations of logGI50 of Indian natural products with protein-changing SNVs in cancer-related genes, which are listed in Table 3. Shown are significant associations with FDR adjusted p < 0.05. INPs are presented by colored circles, with colors corresponding to their subtree assignment based on clustering of their logGI50 values shown in Fig. 1, Supplementary Fig. 1, and Table 1 (orange for subtree 1, red for subtree 2, and purple for subtree 3). The direction of the arrows corresponds to the negative or positive values of the t-statistic in the Student’s t-test. An arrow toward an INP indicates a positive value of the t-statistic, suggesting increased cell line resistance to that INP in the presence of a variant. In contrast, an arrow toward a variant indicates a negative value of the t-statistic, suggesting increased cell line sensitivity to that INP in the presence of a variant.