Additional file 4: Supplementary Figure 4. Comparison of plaques between 5xFAD mice and AppSAA KI/KI mice at 6 months of age. a Representative images of brain sections co-stained with methoxy-X04 and anti-amyloid antibody show plaque pathology in 5xFAD mice and AppSAA KI/KI mice at 6 months of age. Scale bars = 200 μm. b Methoxy-X04 and anti-amyloid co-immunostaining reveals lower proportion of methoxy positive plaques in AppSAA KI/KI mice relative to 5xFAD mice at 6-8 months of age. n=7-8 mice per genotype. Graphs are box and whisker plots and P values: unpaired t test; ***P < 0.001.