1 Citation
Additional file 2: Figure S1. Continuum of CV risk in T2D. T2D is a risk factor for CVD, and several other risk factors are also often present in patients with T2D, as recognised by guidelines such as those of the ESC [38]. Glucose levels alone can be independently linked to progression of CAD [38]. While progression of cardiac disease is thus a feature of T2D, it may in some cases go undetected due to atypical symptom presentation or so-called ‘silent’ manifestations [152, 153], in the proposed ‘unrecognised diabetic cardiac impairment’ phenomenon [48]. Ultimately, overt CVD or heart failure may develop, both of which are prevalent among people living with T2D [4, 48, 152]. CAD, coronary artery disease; CVD, cardiovascular disease; ESC, European Society of Cardiology; MACE, major adverse cardiovascular events; T2D, type 2 diabetes. Figure S2. What to expect next from CVOT-related research. The results of CVOTs have raised several questions that are now being addressed in clinical and scientific studies, chief among which is: how do glucose-lowering drugs produce glucose-independent beneficial effects on cardiorenal outcomes? CVOT, cardiovascular outcomes trial; GLP-1, glucagon like peptide-1; GLP-1 RA, GLP-1 receptor agonist; SGLT2, sodium–glucose transporter 2.