Structural representation of mutation dynamics in Mpro over time. The cumulative number of unique amino-acid exchanges per day (2019/12/24 - 2022/06/22) along the protein sequence of Mpro (PDB entry 7SI9) is represented as a putty figure (spectrum b, blue_white_red, minimum = 0, maximum = 19). Nirmatrelvir, bound to C145, is shown as yellow sticks.