1 Citation
Additional file 3: Fig. S3. Combined treatment decreases oxidative phosphorylation and increases glycolytic reserve in highly aggressive TNBC cells. a. Oxygen Consumption Rate (OCR) measurements in MCF-10A and MDA-MB-231 cells treated with DXR alone or in combination with STS, using Seahorse Analyzer. Combination treatment selectively reduces basal respiration (corresponding to basal OCR), maximal respiration (corresponding to FCCP response) and spare respiratory capacity (the difference between maximal respiration and basal respiration). b. Extracellular Acidification Rate (ECAR) measurements in MCF-10A and MDA-MB-231 cells treated with DXR alone or in combination with STS, using Seahorse Analyzer. Combination treatment selectively increases glycolytic capacity, glycolytic reserve and non-glycolytic acidification in breast cancer cells. Data are presented as mean ECAR ±SD. Ns: non-significant; *P ≤ 0.05.