SUPPLEMENTAL MATERIALSupplemental Table S1. Rationale based on scientific literature to compute the genetic scoreSupplemental Table S2. Effects of the ActiveBrains exercise intervention (intention-to-treat analyses) on Z-score post-intervention outcomes (Z-score of change from baseline) by genetic favourable/unfavourable profilesSupplemental Figure S1. Individual change distribution in reading (panels A and B) and academic skills (panels C and D) for both control and exercise groups, and by genetic profile derived from per-protocol analyses, participants attending to ≥70% of the sessions . Dashed lines indicate a meaningful increase regarding baseline levels. P value from chi-squared test. The standardized score of change indicates how many standard deviations have the post-intervention values changed with respect to the baseline mean and standard deviation. E.g., a 0.70 Z-score means that the value at post-intervention is 0.70 standard deviations higher than the mean value at baseline, indicating a positive change, with negative values indicating the oppositeSupplemental Figure S2. Individual change distribution in working memory (panels A and B) and writing (panels C and D) for both control and exercise groups, and by genetic profile. Dashed lines indicate a meaningful increase regarding baseline levels. Data shown are based on per-protocol analyses, i.e., participants in the exercise group attending to 70% of the recommended sessions. P value from chi-squared test. The standardized score of change indicates how many standard deviations have the post-intervention values changed with respect to the baseline mean and standard deviation. E.g., a 0.70 Z-score means that the value at post-intervention is 0.70 standard deviations higher than the mean value at baseline, indicating a positive change, with negative values indicating the oppositeSupplemental Figure S3. Individual change distribution in reading (panels A and B) and academic skills (panels C and D) for both control and exercise groups, and by genetic profile. Dashed lines indicate a meaningful increase regarding baseline levels. Data analyses were primarily conducted under the intention-to-treat principle. P value from chi-squared. The standardized score of change indicates how many standard deviations have the post-intervention values changed with respect to the baseline mean and standard deviation. E.g., a 0.70 Z-score...