This conceptual paper aims to argue that human traits are biographical and not biological by highlighting the traits of five people who I considered human brands because they changed American society. The Allport (1897 – 1967) trait theory was the lens used in searching for data on these individuals, and the 5-Factor Model of Personality theory was applied when organizing and analyzing how their traits where developed. Certain human traits (i.e., being articulate) can be considered a stimulus for behavior-change. Human brands can influence automatic behavior reaction. In reviewing narratives of previously published studies that focus was on the lives of these five human brands that changed the world, traits are identified and in conclusion compared to those traits of Oprah Winfrey for differences as to why she is considered the most powerful human brand in the world. One of the individuals is the richest man in the world, so I wondered what trait she possesses the others did not. To highlight the differences in trait influences the Thorndike (1874 – 1949) stimulus–response theory was applied in conclusion. It is my aim that this paper creates dialogue on predicting, constructing, or ensuring through life experiences human traits that will create a person that can be identified as one that will have a major influence on society. Human attributes are scientifically linked with human influence and social change. My argument is supported by the common traits found in the five human brands.