Hemodynamic characteristics play a critical role in the pathophysiology of intracranial aneurysms (IAs). Unfortunately, a benchmarked pathway to secure accurate hemodynamic information using computational fluid dynamics (CFD) modeling is still not agreed upon. Therefore, most existing hemodynamic investigations are not applicable in the neurointerventional practice. To bridge this knowledge gap, we developed several benchmarked pathways to conduct high-fidelity CFD modeling for hemodynamic predictions in IAs. Specifically, (1) a set of procedures (i.e., qualified medical images, noise reduction, appropriate smoothing algorithms with associated factors and iterations) was designated for the anatomical model reconstruction of IAs based on the digital subtraction angiography (DSA) information, which ensures the anatomical artery geometry can be reproduced by other research groups. (2) A pathway to mesh IA models, especially the near-wall regions, and to conduct mesh independence tests were designed to secure the proper mesh quality for hemodynamic modeling based on the balance of simulation time and modeling accuracy. (3) An experimental validation procedure was developed to validate the non-Newtonian CFD IA model using in-vitro experimental data (i.e., particle image velocimetry (PIV) measurements) on the same model involving: (a) the non-Newtonian viscosity-shear rate model of blood, derived from experimental tests; and (b) laminar-to-turbulence pulsatile blood flow model. The patient-specific CFD IA model was validated via the acceptable congruency of hemodynamic characteristics (i.e., normalized magnitude of velocity, volumetric flow rate, distributions of velocity vectors, velocity profiles, and streamlines) between in-silico and in-vitro tests using the PIV measurements and CFD modeling at multiple designated time instances within a cardiac cycle. (4) A pathway to secure accurate patient-specific BCs for hemodynamic modeling was developed using transcranial Doppler (TCD) ultrasonography measurements and the discrete Fourier transform (DFT) simulation. Using the described benchmarked pathways to conduct hemodynamic modeling can strengthen the IA research results and allow for more accurate hemodynamic risk information for IA pathophysiology diagnosis.