Number of genes that were up-regulated (magenta), down-regulated (blue), or had a mixed response (gray) to the suppression of , , and . (B) The same Venn diagram as (A) after removing genes with possible indirect effects. (C) Comparison of gene responses to the suppression of and (TTGs of POU5F1 that were down-regulated after suppression): response time ratio = log10(/) where and are response times to and suppression, respectively; difference of response magnitude = - , where and are response magnitudes (log-ratios) to and suppression, respectively; genes in the blue quadrant responded more strongly and faster to suppression than to suppression, and genes in the yellow quadrant responded more strongly and faster to suppression than to suppression. (D) Comparison of gene responses to the suppression of and (TTGs of that were down-regulated after suppression); notations are the same as in (C).Copyright information:Taken from "Identification of , , and downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data"http://www.biomedcentral.com/1471-2164/9/269BMC Genomics 2008;9():269-269.Published online 3 Jun 2008PMCID:PMC2424064.