Copyright information:Taken from "Ensembl 2005"Nucleic Acids Research 2004 ;33(Database Issue):D447-D453.Published online 17 Dec 2004 PMCID:PMC540092.Copyright © 2005 Oxford University Press This new gene-centric view shows in a single display the genomic context of a gene and its surrounding SNPs. The figure shows the region of the human genome around the gene in the HOX cluster on chromosome 17. The display shows three different resolutions: the genes over a 270 kb region are shown around ; the gene itself (gene id ENSG00000120093) and the HOXB3 transcript (transcript id ENST00000311626) with intragenic sequence and introns truncated so that it is mainly CDS and untranslated region (UTR) sequence that is shown. By default the flanking regions are truncated to 50 bp. This can be changed with the ‘Context’ menu and in this case has been set to 200 bp, revealing six intronic SNPs. It can be seen that the CDS of the transcript includes one known protein domain (the Pfam PF00046 homeobox domain). There are only two SNPs that fall within the CDS and only one of these is non-synonyomous leading to a proline (P) to threonine (T) amino acid change in the second exon as a result of an A to C base change. There is a further flanking SNP (C to T change) in the 3′-UTR. A table immediately below the figure provides more information about the SNPs that intersect the transcript being viewed. The three menu bars ‘SNP class’, ‘Validation’ and ‘SNP type’ allow the SNPs being displayed to be filtered. If there were multiple transcripts for the gene selected, they would each be displayed. The view thus combines data in a single view that can partly be found in contigview, transview, protview and snpview.