Copyright information:Taken from "An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene Interactions on risk of myocardial infarction: The importance of model validation"BMC Bioinformatics 2004;5():49-49.Published online 30 Apr 2004PMCID:PMC419697.Copyright © 2004 Coffey et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Darker shade indicates those combinations that were classified as high-risk in the original analysis while lighter shade indicates those combinations that were classified as low-risk in the original analysis. Note that each genotype combination contains a nearly even split of cases and controls. Hence the significant interaction observed in the initial dataset does not appear to validate.