Copyright information:Taken from "The unusually large telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus"Nucleic Acids Research 2005;33(3):1111-1122.Published online 18 Feb 2005PMCID:PMC549419.© The Author 2005. Published by Oxford University Press. All rights reserved We speculate that a sub-compartment of the nucleolus (green) is the location where telomerase complex (red) is assembled and stored. When telomeres (yellow) replicate, two scenarios can be envisioned. A, A subfraction (undetectable by IF) of the assembled/active telomerase is released from the sub-nucleolar compartment and goes to the telomeres, where replication takes place. B, Telomeres form a bouquet-like structure during mitosis and move to the proximity of the nucleolus. Telomerase replicates the chromosome ends, while remaining anchored in the nucleolus.