Copyright information:Taken from "Ensembl 2006"Nucleic Acids Research 2005;34(Database issue):D556-D561.Published online 28 Dec 2005PMCID:PMC1347495.© The Author 2006. Published by Oxford University Press. All rights reserved The proteinview page of Ensembl shows the beta-globin gene HBB on chromosome 11. One of the non-synonymous SNPs is the sickle cell mutation at residue 7 (glutamic acid to valine). The DAS track shows a link to the PDB entry 1A3N chain B. In the SPICE window, which was opened by clicking on this track, the four chain structure of haemoglobin is shown on the left. The DAS annotations for the selected chain (B) are shown on the right. The SNP DAS source is selected and the six SNPs are highlighted in the sequence of the chain (bottom right) and shown in the structure (dark green side chains with yellow highlights). Holding the mouse over residues in the structure panel shows the position of residue 7. Ensembl exposes its precalculated alignments between UniProt and Ensembl gene annotation as DAS sources ().