Copyright information:Taken from "Impact of HIV-1 Subtype and Antiretroviral Therapy on Protease and Reverse Transcriptase Genotype: Results of a Global Collaboration"PLoS Medicine 2005;2(4):-.Published online 26 Apr 2005PMCID:PMC1087220.Copyright: © 2005 Kantor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited In both, the first line lists the drug-resistance positions. The second line shows single-letter amino acid codes for the consensus B sequence. For each subtype (left column), the frequency of specific mutations in untreated persons is shown above the dashed line, whereas the frequency of specific mutations in treated persons is shown below the dashed line. Positions with significant differences in mutation frequency between B and non-B subtypes ( < 0.01, according to χ test with Yate's correction) are circled. A pound sign indicates an insertion.