Table S2. Filtered variants detected in three or more patients. Chromosome, start, end - genome coordinates of variant; Ref/Alt - reference/alternative variant sequence. GT - genotype detected in a given sample (0 - reference, 1-alternative). DP - number of high quality reads at a given position in a given patient. Func.refGene - location of variant relative to gene. Gene - symbol of a gene the given variant maps to, or names of genes the given variants maps in between. GeneDetail.refGene - refSeq gene ID or distance to nearest gene given in the “Gene” column. ExAC_XXX - frequency of the alternative variant in XXX population according to ExAC database. 1000g_all/eur - variant frequency in the 1000 Genomes Project database (total/European). esp6500siv2_all - variant frequency according to National Heart, Lung, and Blood Institute GO Exome Sequencing Project. SIFT/Polyphen2/LRT/FATHMM/RadialSVM “_pred” - prediction of variant impact on protein structure: B-benign, N-neutral, T-tolerated, D-deleterious. ICGC_Id - variant ID in ICGC database (known cancer-related variants). Heterozygous variants are marked orange, homozygous are marked red. (XLSX 34 kb)