D and orange) bound to two hTR isoforms highlights the conformational variability associated with the Ser277 and Asn331 residues. This variability is mostly a result of the lack of the amine group in GC-1, but its presence in T.Copyright information:Taken from "Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms"http://www.biomedcentral.com/1472-6807/8/8BMC Structural Biology 2008;8():8-8.Published online 31 Jan 2008PMCID:PMC2275733.