HP1β is diffuse in nuclei of undifferentiated/pluripotent murine cells and localizes in foci in the course of differentiation. Time lapse spinning disk confocal video of ESCs expressing the endogenous HP1β fused to mCherry induced to differentiate with 1 μM of retinoic acid for 40 h (time scale in the right upper part of the video). (AVI 16.5 mb)