Location of genetic aberrations for Japanese and US patients, and TCGA samples. Mutations in (A) APC, (B) ERBB2, (C) TP53, (D) NRAS, and (E) KRAS for Japanese patients (n = 201), US patients (n = 108), and TCGA samples (n = 224) were aligned to protein domains. The number of mutations at each given amino acid were plotted in corresponding pie graphs. As shown, KRAS G12 were the highest frequency mutations. Patient samples were further plotted by mutation status (F) KRAS-hypermutated and (G) KRAS-non-hypermutated. Figure S2. Correlation of RNF43 mutations with MMR. (A) The frequencies of APC and RNF43 mutations were determined by MMR phenotype. Statistical significance was determined by Fisher’s exact test. (B) Mutation mapper analysis identified G659 as most frequently altered in MMR-D cases. Figure S3. Gene-based statistical analysis for clinical information. Genes were filtered based on Fisher’s exact test (p